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Hepatic biotransformation of MLN8054 was researched in vitro making use of human liver S9 fractions (Information on file, Millennium). Glucuronidation with the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant system of biotransformation, Hydroxylation on the azepine moiety of MLN8054 was the key section one biotransformation

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